Milan of Lidl-Trek went to the front close to the line and, despite the best efforts of Australia's Kaden Groves (Alpecin-Deceuninck), the Italian held on to make up for missing out on winning stage three when he was outsprinted by Tim Merlier.

"I have so many emotions now. I said from the beginning we came here with one goal for everyone. So today the guys did an amazing job," Milan said.

Germany's Phil Bauhaus of Bahrain Victorious finished third on the 190km ride from Acqui Terme to Andora, which featured a very early breakaway before the peloton brought them back to set up the expected sprint finish.

Race favourite Pogacar remained 46 seconds ahead of Geraint Thomas of Ineos Grenadiers, with Colombia's Daniel Martinez (BORA-Hansgrohe) a further second back in third.

Three riders, Lilian Calmejane (Intermarché-Wanty), Stefan de Bod (EF Education-EasyPost) and Francisco Munoz (Polti-Kometa) broke away early and the gap opened to over five minutes.

They had a four-minute lead at the top of the only climb of the day, but still had 100km left to ride, and on the descent, Calmejane was dropped.

The peloton chipped away at the breakaways' lead, and the pair were caught with less than 5km left to race before Filippo Ganna launched an attack.

Ganna was unable to outrace the chasing pack and was caught in the final kilometre with Simone Consonni doing the hard work at the front for his Lidl-Trek teammate Milan, who powered to the line ahead of his sprint rivals.

"We saw Filippo Ganna going full gas in the last climb, we catch him with 900 metres to go," Milan said.

"He also helped us in a way, let's say. And then Simone Consonni did just a fantastic lead-out. I just had to play my cards then."

The Italian won a Giro stage last year where he also took the maglia ciclamino for the points classification, and Milan leads that category after overtaking Merlier who finished fifth.

Eritrea's Biniam Girmay of Intermarche-Wanty, who finished third in stage three, crashed in wet conditions and is out of the race.